CFDE Information Portal

CFDE Workbench

InfoDataCloudKnowledgetrainingcoordination

Home

CF Programs

CFDE Centers

Partnerships

Training & Outreach

Publications

Webinars

About

CFDE Workbench

Stimulating Peripheral Activity to Relieve Conditions (SPARC)

The Common Fund’s Stimulating Peripheral Activity to Relieve Conditions (SPARC) program accelerates development of therapeutic devices that modulate electrical activity in nerves to improve organ function. This therapeutic strategy, also known as “bioelectronic medicine,” could offer new treatment options for diverse diseases and conditions such as hypertension, heart failure, gastrointestinal disorders, and more. (Retrieved from the NIH Common Fund site)

Metadata and Processed Data Files

C2M2

1 Current File(s) | 4 Archived File(s)

1 Current File(s)

4 Archived File(s)

Modified 3/17/2026

Current

Filename:
C2M2_datapackage_20260317.zip
Creator: SPARC
Filesize: 26.3 Mb
Date Modified: 3/17/2026
DCC Approved:
DRC Approved:

Archived

Filename:
C2M2_datapackage_20251215.zip
Creator: SPARC
Filesize: 24.1 Mb
Date Modified: 12/16/2025
DCC Approved:
DRC Approved:

Filename:
C2M2_datapackage_202509.zip
Creator: SPARC
Filesize: 20.6 Mb
Date Modified: 9/23/2025
DCC Approved:
DRC Approved:

Filename:
c2m2_2025MAR18_submit.zip
Creator: SPARC
Filesize: 27.8 Mb
Date Modified: 3/19/2025
DCC Approved:
DRC Approved:

Filename:
c2m2_2024DEC16_sparc.zip
Creator: SPARC
Filesize: 18.1 Mb
Date Modified: 12/17/2024
DCC Approved:
DRC Approved:

XMT

0 Available Files

Current

None Available

Archived

None Available

Attribute Tables

0 Available Files

Current

None Available

Archived

None Available

Knowledge Graph Assertions

1 Current File(s) | 1 Archived File(s)

1 Current File(s)

1 Archived File(s)

Modified 4/23/2026

Current

Filename:
SPARC-SCKAN-2026FEB.zip
Creator: SPARC
Filesize: 944.1 Kb
Date Modified: 4/23/2026
DCC Approved:
DRC Approved:

Archived

Filename:
SPARC-SCKAN-2025MAY.zip
Creator: SPARC
Filesize: 1.4 Mb
Date Modified: 5/22/2025
DCC Approved:
DRC Approved:

Interoperability Assets

ETL Scripts

0 Available Files

Current

None Available

Archived

None Available

API Specifications

1 Current File(s) | 0 Archived File(s)

1 Current File(s)

0 Archived File(s)

Modified 2/18/2026

Current

Name:
Pennsieve API (OpenAPI)
Creator: SPARC
Date Modified: 2/18/2026
DCC Approved:
DRC Approved:

Archived

None Available

Entity Pages

0 Available Files

Current

None Available

Archived

None Available

PWB Metanodes

0 Available Files

Current

None Available

Archived

None Available

Models

43 Current File(s) | 0 Archived File(s)

43 Current File(s)

0 Archived File(s)

Modified 4/10/2026

Current

Name:
CellML model of ATPase pumps: Calcium ATPase (SERCA)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of Hydrogen-potassium ATPase (HKE)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of Inositol triphosphate receptor
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of K ATP
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of KACh
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of Kp
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of NaB
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of Sodium calcium exchanger
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of T-type calcium pump CaT.
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of calcium buffer troponin
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of cardiac G-protein coupled receptor
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of cyclic AMP (cAMP) and adenylyl cyclase (AC) metabolism in the cardiac cell.
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of inhibitor-1 (Inhib1)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of ligand binding a receptor
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of phospholamban (PLB)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of plasma membrane calcium-transporting ATPase (PMCA)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of potassium delayed rectifier channel
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of protein kinase A (PKA)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of receptor tyrosine kinase (RTK)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of role of cyclic guanosine monophosphate (cGMP) in muscle relaxation
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of ryanodine receptor (Ryr)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of slow delayed rectifier potassium channel
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of sodium hydrogen exchanger
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of sodium potassium exchanger
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of sodium potassium exchanger
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of sodium-driven chloride-bicarbonate exchanger
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of soluble guanylyl cyclase enzyme (sGC)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the ABC channel operating under normal physiological conditions
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the ATPase pumps: Hydrogen ATPase (Proton pump)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the L-type calcium pump CaL.
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the SLC family: AE3 (SLC4A3)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the SLC family: EAAT2 (SLC1A2)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the SLC2A2 (GLUT2) transporter.
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the chloride hydroxide exchanger (CHE).
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the membrane proteins constituting the background calcium current (CaB)
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the metabolism of the G-protein coupled receptor (muscarinic acetylcholine M2 receptor, R) and the associated Gi protein in the cardiac cell.
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the pacemaker channel HCN (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel).
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of the sodium bicarbonate cotransporter
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of transient outward potassium current
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of transport of glucose and sodium through the SGLT1 transporter
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
CellML model of voltage-gated sodium potassium channel
Creator: SPARC
Date Modified: 6/6/2025
DCC Approved:
DRC Approved:

Name:
SimVuer
Creator: SPARC
Date Modified: 10/9/2025
DCC Approved:
DRC Approved:

Name:
𝐀𝐩𝐢𝐍𝐀𝐓𝐎𝐌𝐘 𝐑𝐞𝐧𝐚𝐥 𝐂𝐨𝐧𝐧𝐞𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐌𝐨𝐝𝐞𝐥
Creator: SPARC
Date Modified: 4/10/2026
DCC Approved:
DRC Approved:

Archived

None Available

Apps URLs

2 Current File(s) | 0 Archived File(s)

2 Current File(s)

0 Archived File(s)

Modified 2/17/2026

Current

Name:
SPARC Apps
Creator: SPARC
Date Modified: 2/17/2026
DCC Approved:
DRC Approved:

Name:
Tools useful for the SPARC community
Creator: SPARC
Date Modified: 2/17/2026
DCC Approved:
DRC Approved:

Archived

None Available

Landmark Publication

The SPARC DRC: Building a Resource for the Autonomic Nervous System Community.Osanlouy M et al. | Frontiers in physiology | Published: 2021

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.

Stimulating Peripheral Activity to Relieve Conditions (SPARC)

Metadata and Processed Data Files

Current

Archived

Current

Archived

Current

Archived

Current

Archived

Interoperability Assets

Current

Archived

Current

Archived

Current

Archived

Current

Archived

Current

Archived

Current

Archived

Go to data matrix

Landmark Publication

Consortium

Community

Resources

Consortium

Community

Resources