To further characterize associations between small molecule compounds and their potential to induce specific birth abnormalities, we gathered knowledge from multiple sources to construct a reproductive toxicity Knowledge Graph (ReproTox-KG) with a focus on associations between birth defects, drugs, and genes.
FEATURED
Playbook Workflow Builder
The Playbook Workflow Builder (PWB) is a web-based platform that facilitates knowledge resolution by enabling users to traverse an ever-growing network of input datasets, semantically annotated API endpoints, and data visualization tools. Via a user-friendly user-interface, workflows can be constructed from these building-blocks without technical expertise. The output of these workflows is provided as reports containing textual descriptions, interactive figures, and downloadable tables.
FEATURED
Standard RNA-seq Processing Pipelines
The CFDE RNA-seq Pipeline Harmonization partnership is a collaboration between multiple DCCs (GTEx, UDN, KF, HuBMAP, SPARC, MoTrPAC) to update their RNA-seq pipelines across the DCCs with a revised version of the STAR RNA-seq aligner. The goal is to enable uniform alignment to a reference genome by reprocessing all the existing accessible bulk-tissue RNA-seq datasets.
ALL TOOLS AND WORKFLOWS
Explore different tools and workflows that utilizes data from different CFDE participating programs
FAIRshake
Toolkit to evaluate the FAIRness of research digital resources
Publications:
GDLPA
Query 53 gene-centric, 18 variant-centric, and 19 drug-centric repositories
Publications:
ReproTox-KG
Toxicology knowledge graph for structural birth defects
Publications:
Data Distillery Knowledge Graph
KG database represents interrelated biomedical ontologies and vocabularies
Playbook Workflow Builder
Web-based platform to construct biomedical workflows
Standard RNA-seq Processing Pipelines
Revised STAR RNA-seq aligner to update RNA-seq pipelines across CF programs