f65babf7-2875-5725-9635-210d654533f1

Extracellular RNA Communication (ExRNA)

The Extracellular RNA Communication program is exploring the biology of extracellular RNA (exRNA). Once thought to exist only within cells, in a paradigm shift for science, RNA is now known to be exported from cells as “extracellular RNA” and to play a role in cell-to-cell communication. Since its founding, the program has established data standards, a data portal, and tools and reagents available to the scientific community. The program cataloged exRNA molecules found in human biofluids like plasma, saliva, and urine from over 2000 donors. It also identified potential exRNA biomarkers for nearly 30 diseases, including cardiovascular disease, pregnancy complications, glaucoma, diabetes, and multiple types of cancer. (Retrieved from the NIH Common Fund site)

TRAINING & OUTREACH

CFDE Webinar Series

The CFDE Webinar Series will feature the exRNA DCC. The seminar will be about ‘Tools and methods for discovering disease-causing gene regulatory variants from WGS data with application to Congenital Heart Disease’ presented by Keyang Yu, a Genboree Research Assistant.

Starts: September 27, 2024

Biomarker discovery from extracellular (cell-free) RNA-seq and tissue of origin from GTEx RNA-seq profiles

Join us for an engaging hands-on workshop where Meenu Srinivasan of the Louise Laurent Lab at the University of California-San Diego will demonstrate how to perform integrative data analysis utilizing data from two Common Fund Data Ecosystem (CFDE) Data Coordinating Center portals followed by an interactive Q&A session.

Starts: September 12, 2024

Metadata and Processed Data Files

Current
FilenameCreatorFilesizeDate ModifiedDCC ApprovedDRC Approved
CFDE_20241216_2.zipExRNA12.0 Mb12/18/2024
Archived
FilenameCreatorFilesizeDate ModifiedDCC ApprovedDRC Approved
datapackage.zipExRNA11.1 Mb8/17/2023
datapackage.zipExRNA10.7 Mb3/23/2023
datapackage.zipExRNA53.3 Mb4/16/2022
datapackage.zipExRNA7.0 Mb1/21/2022
datapackage.zipExRNA5.6 Mb8/19/2021
datapackage.zipExRNA5.4 Mb6/11/2021
datapackage.zipExRNA5.4 Mb3/18/2021
Current
FilenameCreatorFilesizeDate ModifiedDCC ApprovedDRC Approved
RBP_unique_loci_in_biofluids.rbpmtExRNA399.1 Kb9/25/2024
Archived
FilenameCreatorFilesizeDate ModifiedDCC ApprovedDRC Approved
RBP_unique_loci_in_biofluids.rbpmtExRNA398.7 Kb9/24/2024
Current

None Available

Archived

None Available

Current
FilenameCreatorFilesizeDate ModifiedDCC ApprovedDRC Approved
ERCC.zipExRNA461.4 Mb5/8/2024
Archived
FilenameCreatorFilesizeDate ModifiedDCC ApprovedDRC Approved
ERCC.edges.csvDRC4.6 Gb10/26/2023

Interoperability Assets

Current

None Available

Archived

None Available

Current
NameCreatorDate ModifiedDCC ApprovedDRC Approved
Allele RegistryDRC8/29/2019
CFDE GeneReg Linked Data HubDRC8/30/2022
Linked Data HubDRC9/5/2019

exRNA Atlas JSON-LD (OpenAPI)

DRC2/20/2019
Archived

None Available

Current
NameCreatorDate ModifiedDCC ApprovedDRC Approved

CFDE Gene Regulatory Elements
Template | Example

ExRNA10/3/2024
Archived

None Available

Current
NameCreatorDate ModifiedDCC ApprovedDRC Approved
GeneInfoDRC10/19/2023
Regulatory ElementDRC10/19/2023
Regulatory Element InfoDRC10/19/2023
Regulatory Element InfoDRC10/19/2023
VariantDRC10/19/2023
VariantDRC10/19/2023
VariantInfoDRC10/19/2023
VariantInfoDRC10/19/2023
Archived

None Available

Current

None Available

Archived

None Available

Current

None Available

Archived

None Available